Is functional medicine evidence-based?

Yes. Functional medicine uses the same peer-reviewed research as conventional medicine — it just applies different clinical thresholds. Optimal ferritin, TSH, and insulin ranges are derived from outcomes research, not arbitrary preference. The difference is in interpretation, not rigor.

Do I need a functional medicine doctor to use functional ranges?

No. Many conventional providers will adjust treatment based on functional thresholds if you bring the research and explain what you're experiencing. Aliza gives you the language and context to have that conversation — your provider still makes the prescribing decision.

Why doesn't conventional medicine use optimal ranges?

Conventional medicine is designed to identify and manage disease, not optimize function. A ferritin of 15 ng/mL won't cause anemia, so it's considered normal. Functional medicine asks a different question: what level supports energy production, thyroid conversion, and tissue repair? The answer is 70 ng/mL or higher. It's not that one approach is wrong — they're solving for different outcomes.

Functional vs. conventional

What's the Actual Difference Between Functional Medicine and Conventional Medicine?

If your labs came back "normal" but you still feel terrible, or you've been managing symptoms for years without anyone asking why they started, this explains what functional medicine actually does differently.

The Mechanism: Two Different Definitions of Normal

Conventional medicine uses statistical reference ranges — the values that capture 95% of the population. If your ferritin is 15 ng/mL, it's technically normal because it falls within the lab's printed range of 12-150 ng/mL. The reference range tells you what's common, not what's optimal.

Functional medicine uses optimal ranges — the values associated with actual physiological function. Ferritin below 70 ng/mL impairs thyroid conversion, slows cellular energy production, and increases hair loss. The number 15 might be statistically normal, but functionally, it's deficient.

This distinction applies to every marker. TSH between 1.0-2.5 mIU/L supports healthy thyroid function. The conventional range allows up to 4.5 or 5.0 mIU/L — a level at which many women experience fatigue, weight gain, and brain fog. Fasting insulin below 5 µIU/mL indicates good insulin sensitivity. The conventional range considers anything under 25 µIU/mL normal, even though insulin resistance begins to develop well before that threshold.

In perimenopause, this gap becomes critical. Serum estradiol around 125 pg/mL supports cognitive function, bone density, and metabolic health. But conventional HRT often produces levels of 50-80 pg/mL — technically within range, physiologically insufficient.

Functional medicine doesn't reject conventional lab work. It reads the same numbers through a different lens: not whether you're in the reference range, but whether your levels support the biological processes they're meant to regulate.

What This Looks Like

Your ferritin is 22 ng/mL. Conventional: normal. Functional: explains the hair loss and afternoon crashes.
Your TSH is 3.8 mIU/L. Conventional: fine. Functional: explains why you can't lose weight and sleep poorly.
Your fasting insulin is 12 µIU/mL. Conventional: unremarkable. Functional: early insulin resistance driving cravings and belly fat.
Your estradiol on HRT is 65 pg/mL. Conventional: stable dose. Functional: under-dosed, which is why brain fog persists.
You report fatigue, weight gain, disrupted sleep, and low mood. Conventional: separate issues, separate treatments. Functional: one upstream cause affecting multiple systems.

What Actually Helps

Functional medicine starts with comprehensive lab work read through optimal ranges, then builds a protocol that addresses root causes in sequence. This is not guesswork or trend-chasing. It's clinical decision-making based on what the body actually needs to function.

Aliza applies this framework specifically to perimenopause and post-menopause. The platform reads your labs — ferritin, thyroid panel, fasting insulin, vitamin D, hormone levels — and generates a protocol that restores function in the right order. Replete deficiencies first. Clear metabolic dysfunction second. Then support or replace hormones.

The AI coach is built on Claude and draws from educational content and protocols developed from Brie's 27 years in practice. It can use the context you choose to share and your weekly check-ins to provide educational guidance over time. It does not diagnose or prescribe — it educates you on what your labs mean functionally and helps you have informed conversations with your provider.

If you're on HRT, Aliza can help you organize your symptoms and existing lab results and prepare questions about them for your own clinician. If your provider is working from conventional ranges, this becomes the bridge — you bring functional context to the conversation, and your provider makes the prescribing decision.

Aliza may offer optional educational supplement suggestions. Any Fullscript purchase is optional and self-directed; Aliza does not sell branded Reverse Age products or prescribe hormones or medications.

When to Get Additional Support

If your symptoms are severe — debilitating anxiety, uncontrolled bleeding, significant bone density loss, cardiovascular changes — you need a practitioner who can order labs, prescribe appropriately, and monitor your response in real time. Functional medicine excels at optimization, but acute or high-risk situations require direct clinical oversight. Aliza is built to work alongside your provider, not replace them.

How Aliza fits

Aliza provides educational AI coaching, not diagnosis, prescribing, medication dosing, or a clinician-reviewed treatment plan. Hormone and medication decisions belong with your own clinician.

Labs are optional, and Aliza does not order them. Members may upload existing serum, DUTCH, GI-MAP or other stool, ION, and NutrEval reports for educational interpretation using functional reference points; not every marker or report is guaranteed to be interpretable.

Fullscript suggestions and purchases are optional and self-directed.

Brie Wieselman, L.Ac., has 27 years of functional-medicine clinical experience, informed by more than 3,000 deidentified patient charts.

Common Questions

Is functional medicine evidence-based?: Yes. Functional medicine uses the same peer-reviewed research as conventional medicine — it just applies different clinical thresholds. Optimal ferritin, TSH, and insulin ranges are derived from outcomes research, not arbitrary preference. The difference is in interpretation, not rigor.
Do I need a functional medicine doctor to use functional ranges?: No. Many conventional providers will adjust treatment based on functional thresholds if you bring the research and explain what you're experiencing. Aliza gives you the language and context to have that conversation — your provider still makes the prescribing decision.
Why doesn't conventional medicine use optimal ranges?: Conventional medicine is designed to identify and manage disease, not optimize function. A ferritin of 15 ng/mL won't cause anemia, so it's considered normal. Functional medicine asks a different question: what level supports energy production, thyroid conversion, and tissue repair? The answer is 70 ng/mL or higher. It's not that one approach is wrong — they're solving for different outcomes.